Factors influencing sequence choice in MRI

For any imaging protocol, it is the specific combination of sequences that determines the diagnostic efficacy of the examination. It is clear that imaging protocols vary between institutions. This is largely because rapid advances in imaging technology and variations between manufacturers, applied in the context of investigating relatively rare disorders, precludes an effective evidence-based approach to sequence choice.
The main advantages that MRI offers over alternative imaging modalities is the ability to demonstrate different tissue contrasts (principally T1-W, T2-W and spin density, but also flow and diffusion) in multiple imaging planes (principally sagittal, coronal and axial). The disadvantage of MRI is the artefacts that it generates in almost every image.
The choice of sequence combination should reflect the multicontrast and multiplanar capabilities of MRI. We have found that applying the generic principle of combining T2-W images in two planes, supported by T1-W imaging in two planes, as the basis of our imaging protocols, serves to optimize the benefits of MRI whilst minimizing the impact of artefacts.