DTI fiber tractography in MS

Recently, there has been interest in using fiber tractography obtained from DTI datasets in characterizing white matter tract directionality and integrity in relation to MS lesions. It has been found that lesions can be shown to transect white matter fiber tracts in a similar manner to that of brain tumors. Fiber tractography has a potential role in quantifying the degree of axonal loss and demyelination within different lesion types and NAWM. The differences in white matter tract disruption can be visualized directly, which may help to explain the association between lesion type and location with clinical symptomatology and may help in monitoring disease progression