Extravasation of Gadolinium-Based Contrast Media
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The incidence of extravasation in one series of 28,000 doses was 0.05%. Laboratory studies in animals have demonstrated that both gadopentetate dimeglumine and gadoteridol are much less toxic to the skin and subcutaneous tissues than are equal volumes of iodinated contrast media. The small volumes typically injected for MR studies limit the chances for a compartment syndrome. For these reasons the likelihood of a significant injury resulting from extravasated MR contrast media is extremely low. Nonionic MR contrast media are less likely to cause symptomatic extravasation than hypertonic agents such as gadopentate dimeglumine.
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