The new 9.4 tesla MRI scanner installed in University of Illinois, Chicago is the world’s most powerful MRI machine used on humans .
With the ultrapowerful MRI, the scientists can measure sodium concentration, oxygen consumption and the brain cells’ energy usage. When combined, the three “bioscales” provide a detailed picture of tissue health within the brain, possibly allowing scientists to pinpoint neurodegenerative disease long before symptoms show up.
Current MRI visualizes water molecules to track biochemical processes. By visualizing the sodium ions involved in those processes instead, the 9.4T permits researchers to directly follow one of the most important energy-consuming processes in the cellular machinery in the brain.
The strength of magnetic resonance scanners has increased from less than 0.5T up to the first 8T in 1998. As human safety data became available, the FDA limits were revised upwards accordingly -- to the current level of 8T in 2003.
In this safety trial, 25 healthy volunteers -- 12 men and 13 women -- were exposed, in random order, to the 9.4T scanner, in which they were exposed to a static magnetic field and to sodium imaging, and to a mock scanner with no magnetic field. An audio recording simulated the sound of a real scanner.Vital signs and cognitive ability were measured in all volunteers before and after the sodium imaging at 9.4T and the mock scanning. There were no significant changes in heart rate, blood pressure, respiratory rate or other vital signs when volunteers were exposed to either the magnetic field or the imaging. There were no significant differences in the cognitive testing of volunteers following mock vs. real scanning.
The most frequently reported discomfort was lightheadedness or vertigo when being moved into the magnetic field. A few subjects reported a metallic taste, nausea, or a visual effect of seeing sparks. The sensations went away once they were stationary in the magnetic field.
The researchers concluded that exposure to a 9.4T static magnetic field does not present a safety concern.
With the FDA-required safety trials completed, UIC researchers will begin to put the 9.4T to use.
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