In previous studies, ADC has been evaluated as a possible biomarker of necrotic areas in metastatic cervical lymph nodes from HNSCC [7, 8]. Recently, in two different studies of necrotic cervical nodes, the authors reported that DWI was helpful in distinguishing tuberculous lymphadenitis from malignancy, and suppurative lymphadenitis from malignancy. Zhang et al. [9] found that the mean ADC value for necrosis was higher in the necrotic portions of metastatic nodes (2.02 ± 0.36 × 10−3 mm2 s−1) than in tuberculous nodes (1.25 ± 0.15 × 10−3 mm2 s−1) (p < 0.01). In addition, the optimum ADC threshold for distinguishing between metastasis and tuberculosis was 1.59 × 10−3 mm2 s−1, with sensitivity and specificity of 88 and 100 %, respectively. This was also corroborated in another study by Kato et al. [10] in which the ADC of necrotic cervical nodes was shown to be higher in metastatic nodes (1.46 ± 0.50 × 10−3 mm2 s−1) than in tuberculous nodes (089 ± 0.21 × 10−3 mm2 s−1) (p < 0.01). Thus, ADC could prove useful for identification of metastatic nodes in populations in which granulomatous infections such as tuberculosis are also endemic.
Lymph Node Characterization by Use of ADC IN NECK MRI
In previous studies, ADC has been evaluated as a possible biomarker of necrotic areas in metastatic cervical lymph nodes from HNSCC [7, 8]. Recently, in two different studies of necrotic cervical nodes, the authors reported that DWI was helpful in distinguishing tuberculous lymphadenitis from malignancy, and suppurative lymphadenitis from malignancy. Zhang et al. [9] found that the mean ADC value for necrosis was higher in the necrotic portions of metastatic nodes (2.02 ± 0.36 × 10−3 mm2 s−1) than in tuberculous nodes (1.25 ± 0.15 × 10−3 mm2 s−1) (p < 0.01). In addition, the optimum ADC threshold for distinguishing between metastasis and tuberculosis was 1.59 × 10−3 mm2 s−1, with sensitivity and specificity of 88 and 100 %, respectively. This was also corroborated in another study by Kato et al. [10] in which the ADC of necrotic cervical nodes was shown to be higher in metastatic nodes (1.46 ± 0.50 × 10−3 mm2 s−1) than in tuberculous nodes (089 ± 0.21 × 10−3 mm2 s−1) (p < 0.01). Thus, ADC could prove useful for identification of metastatic nodes in populations in which granulomatous infections such as tuberculosis are also endemic.
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