Secretin is injected intravenously at the time of the MRCP. Images are then taken every 30 seconds for 10 minutes. Maximum output of pancreatic fluid is optimal between 6 to 8 minutes. A dynamic image and video is created from a 3-D rendering by the radiologist. This image sequence examines the pancreas response to stimulation. The excess pancreatic fluid/bicarbonate will resonate a sharper image of the pancreas. Static MRCP’s turn into dynamic images with pancreatic stimulation.
Secretin enhanced MRCP (S-MRCP) relies on dynamic responses of the main pancreatic duct to secrete fluid after Secretin stimulation, which causes the improvement of visual clarity in sharpening pancreatic imaging Secretin is a polypeptide hormone secreted by duodenal mucosa in response to luminal acid . It induces pancreatic secretion of water and bicarbonate. In the first 5–7 minutes, the tone of the sphincter of Oddi is increased. These effects result in temporary distention of the pancreatic ducts. Synthetic human secretin is given IV over 1 minute to avoid potential abdominal pain that may occur with a bolus injection. An adult dose of 16 μg (0.2 μg/kg body weight in children) is used. At the commencement of injection, a baseline scan is obtained, followed by coronal SSFSE images (2-second scanning time) every 30 seconds for 10 minutes. In healthy subjects, the maximal effect of IV secretin is between 7–10 minutes
READ MORE:
Dynamic Coronal MRCP
3D MRCP Pancreas Technique
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