T1 relaxation times get longer-requiring sequence parameter changes.
This may seem counterintuitive—you might at first think that a stronger magnetic field would “pull” the net magnetisation vector of any spin isochromat back to alignment with the external magnetic field more quickly—but this classical picture does not help us here. In fact the T1s usually get longer—slower regrowth of the net magnetisation vector in the z-direction. This has to do with the number of resonant protons which are available to transfer energy to the “lattice”, which depends on field strength.
Let's consider just the structured-water protons (medium range of Ï„c's). How many protons within this set experience an oscillating magnetic field at or near the Larmor frequency? Actually, not all of them, and the proportion is related to the Larmor frequency. Consider this graph:
This graph indicates the number (the spectral- (relating to frequency) density) of protons which are tumbling at or near the Larmor frequency. We are interested in the blue line. If we increase B0, the Larmor frequency increases (move the red line to the right), and so the spectral density at the Larmor frequency reduces. (Don't forget, the Larmor frequency is proportional to B0). So increase the magnetic field strength, and there are fewer protons available to transfer energy efficiently to the lattice, and the T1 time is lengthened.
Source: http://www.revisemri.com/
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